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22. Kongress der DGII 2008
Abstracts DGII 2008
V57
Long term follow of PRK with inraoperative
Mitomycin-C
– Updated cofocal microscopic
examination results
Lee DH
Durham (USA)
Purpose: To evaluate the safety and efficacy of Mitomycin-C (MMC)
during photorefractive keratectomy (PRK). Method: 115 eyes of 59
patients were enrolled in this study. Patients had PRK with intraoperative
MMC for 30 seconds to 2 minutes. Patients were followed
up for 5 years (5 ~ 6 yrs). Visual acuity, refractive error and corneal
haze were measured. Confocal microscopic examinations were done
at 1 and 5 postoperative years. Corneal endothelial counts and keratocyte
population were measured. Results: 76% of eyes were within
0.5 D and 66% of eyes showed more than 20/20. Only 3% of eyes lost
1 line of vision but there were no eyes that lost 2 or more lines.
Corneal hazes happen in 6 eyes. 5 of them showed grade 1 and one
eye was grade2. Corneal endothelial cell counts were not different at
1 and 5 year compared to normal control. At 1 year, keratocyte
density decreased significantly at superficial layer only. But at 5
years, they were significant decrease at all corneal stromal layers.
There was no other severe complication related to MMC toxicity.
Conclusion: MMC is a safe and effective method to prevent corneal
haze.
Erschienen in: Klin Monatsbl Augenheilkd 2008; 225: Suppl 1, S1–S24 |
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